- Company’s Cognitive Network Restoration Therapy (CNRT) technology aims to make meaningful cognitive recovery possible years after initial injury
- Targeting a brain hub involved in executive function, CNRT activates underperforming networks to reverse deficits and restore independence
- Groundbreaking therapeutic approach has the potential to transform chronic cognitive impairment care from rehabilitation to restoration
EDINA, Minn., Sept. 15, 2026 /PRNewswire/ — ReEmerge, Inc. (ReEmerge), a private MedTech company innovating a new way to address cognitive impairment, launched from stealth today following the close of an oversubscribed $37M Series A financing. The proceeds will support an upcoming clinical study that will evaluate ReEmerge’s proprietary Cognitive Network Restoration Therapy (CNRT) in its first clinical indication, traumatic brain injury (TBI), while advancing technology development, expanding clinical and regulatory operations, and preparing the platform for future indications. U.S. Venture Partners (USVP) and Santé co-led the round, with significant participation from Oxford Science Enterprises, 415 Capital, IAG Capital Partners, The Vertical Group, and Dendrion Ventures.
“ReEmerge’s technology represents a fundamentally different approach to cognitive recovery with the potential to transform the recovery pathway,” commented Jonathan Root, MD, General Partner at USVP. “The size of the opportunity and the profound unmet need make this an especially compelling market for innovation. We are excited about this technology and the new hope it aims to offer patients and their families.”
“TBI does not discriminate. It can happen to anyone at any age, and its consequences can fundamentally alter a person’s ability to live, work, and engage with the world around them,” said Auriel August, MD, Principal at Santé. “CNRT could offer people living with TBI something they have too often been told not to expect, namely the possibility of meaningful cognitive recovery.”
CNRT is a proprietary, first-of-its-kind approach that precisely targets neural networks in the central thalamus, a brain hub involved in attention, arousal, and executive function. Rather than bypassing damaged pathways or asking patients to compensate for lost function, CNRT aims to augment the recovery journey by driving underactive but viable neural circuits. By restoring function across existing but underperforming networks, CNRT aims to reverse cognitive deficits and allow recovery to extend further.
This technology grew out of decades of research by Nicholas Schiff, M.D. Professor of Neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine and colleagues at Stanford University and the University of Utah, which explored the possible restorative effect of brain electrical stimulation after TBI. A pilot study showed promising results, with patients regaining cognitive function. The Center for Technology Licensing at Weill Cornell worked closely with Dr. Schiff’s team to protect the intellectual property, provide internal translational gap funding, and license the foundational intellectual property to ReEmerge to advance clinical and commercial development of CNRT.
Building upon this groundbreaking clinical research, including a publication in Nature Medicine, ReEmerge will conduct a prospective, single-arm, multicenter study (NCT07730099) to evaluate this treatment, enrolling up to 40 patients with chronic moderate-to-severe TBI. Additionally, the study will explore potential effects on cognitive and functional outcomes.
“As a physician-scientist and co-founder, it has been very rewarding to see the arc of benchtop science moving forward and being translated into a meaningful clinical development pathway,” stated Dr. Schiff. “I am excited for us to advance the testing of treatment for many patients, who have historically had limited therapeutic options, as we look to shift cognitive care from rehabilitation to restoration and ultimately, to redefine recovery.”
Each year, an estimated 27 million people worldwide experience a traumatic brain injury, and many are left with persistent cognitive impairment.1 Current recovery pathways focus on rehabilitation, helping patients compensate for cognitive deficits through structured routines, adaptive strategies, and supportive therapies. While these interventions can improve function, the journey can be long, and recovery will often plateau, frequently leaving patients with lasting impairments that limit independence, quality of life, and personhood.
“The strong support of our stellar investor syndicate validates our mission to evolve the recovery trajectory for patients living with impaired cognitive function,” said Todd Langevin, Chief Executive Officer of ReEmerge. “We look forward to initiating our clinical study in TBI and building a robust body of evidence to support our differentiated approach to treating cognitive impairment.”